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Emily Campbell | Member Directory | Suzuki Association of the Americas

In a study published in the journal Cell, investigators from Wake Forest Baptist Medical Center have found that, when exposed to radiation, certain cells in the colon migrate to the liver, liver stem cells become activated, and in turn, migrate to the heart in a way that is analogous to what is seen in a tumor growing in the liver.

The heart is the largest and busiest organ in the body, responsible for producing heart beats and pumping blood. Studies have shown that the brain, while it’s a relatively minor organ, is also very dependent on energy for the health and function of our bodies and is dependent on it in many other key ways — such as regulating glucose levels. When the energy needs of the liver and heart are exceeded by the demands of a cancerous tumor or a disease that is not being treated effectively by existing therapies, that is often accompanied with a change in the shape and size of the organs or the number of cells that are present in each organ.

These new studies suggest that the liver’s migration to the heart is associated with several metabolic pathways involving inflammation and the development of tumors and those tumor cells become activated. This is a process that is very similar to what would occur when we encounter a tumor that is growing in the liver. It is also similar to what happens when tumors grow in the brain’s cerebral cortex or in the spleen or on the lining of the kidneys or other large organs. These tumor cells become activated but do not differentiate until they reach the heart.

The researchers discovered that the cell migrations involved in this process are largely dependent on factors that are secreted by the pancreas. One of these factors is a lipid called apocynin, which has been shown to promote cellular migration even before it reaches the tumor or tumor cells and causes their activation before they proceed to tumor formation. Apocynin’s presence also allows the pancreas to regulate the amount of cell migration in response to nutrients.

The research

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